It happened in the 33- hundred block of Fort Bragg Road near Bragg Boulevard.
One firefighter was taken to the hospital with non-life threatening injuries.
Lee Howell says he was inside his flower and home decorating shop on Fort Bragg Road when the fire began.
"I saw fire and my first reaction was --the way the fire was going it was so high-- first thing I did I just got on the phone and dialed 911," Howell said.
The building actually houses several businesses. Howell says he watched helplessly as the blaze wiped away his 10 year old business.
"It was engulfed in flames at least about 20 to 30 feet in the air," he said. "I just, it was over with then."
Eyewitnesses say the flames tore through the roof and burned through power lines.
The fire also destroyed a vacant TV repair shop and burned down Kevin Johnson's Macco Auto Paint Shop.
"It's devastating. I mean, more importantly our customers are important to us and obviously to tell somebody that their car has been completely burned up is a terrible thing," Johnson said.
Michael Ordway wife's vehicle was involved in the blaze.
"I was watching the news and I said there was a bad fire up on Bragg Boulevard I think you just lost your car... joking with my wife. And it turns out we did," he said.
At this time investigators aren't saying what caused the blaze
.