The fire chief told ABC11 Eyewitness News that the investigation is ongoing and the SBI is assisting.
It appears as if the fire started in the back left bedroom where 12-year-old Abria Lewis and 1-year-old Chase Lewis were located. There was a space heater in the home but investigators have not determined if that's the cause.
According to the family's neighbor, the Lewis' have a total of four children. The neighbor told ABC11 the other two children, who were rescued from the home, are a 9-year-old and a 16-year-old. It is believed that the 16-year-old was watching the others while their parents, June and Ayana Lewis, parents were running an errand.
The 16-year-old went next door for help and a neighbor was able to rescue his 9-year-old brother.
The deaths are a deep loss for the close knit-family.
"I'm just feeling sad inside," said Margaret Talley, the children's aunt. "I'm just feeling so sad. They're my nephews and I love them.
Counselors are at Abria's school to help her classmates cope with the loss. The 12-year-old attended Henderson Middle School where her mother is an employee.
Abria's surviving siblings attend Southern Vance High School and Aycock Elementary.