It happened shortly after 1 a.m. at the main entrance of Duke North. One man was killed during the incident.
A university spokesperson said the dead man was taken to The Office of the Chief Medical Examiner in Chapel Hill. He has not yet been positively identified, but Duke said there was no immediate indication that the incident involved an employee, patient or patient family member. Witnesses told ABC11 that the dead man appeared to be in his 40s.
Police Chief John Dailey says one officer was treated for a minor injury.
Dailey identified the officers as Larry Carter, who has been employed by Duke Police for 23 years, and Jeffrey Liberto, who has been employed for two years.
The two officers involved are now on paid leave.
Officials say the incident has the university taking a closer look at its policies and procedures making sure protocol was followed and innocent bystanders were never in harm's way.
Duke University leaders say they will release new details later in the week after a report on the incident is complete.
On Monday, it was business as usual at the hospital with no changes in security.