Deputies got the call around 7 a.m. Sunday about a shooting at 85 Mobley Street in Roanoke Rapids.
Authorities say 55-year-old Michael Wayne Davis was killed, and they are searching for 55-year-old Richard Demello.
Deputies say Demello and Davis knew each other.
Demello is believed to be driving Davis' 1998 blue Plymouth neon with a spoiler - possibly with N.C. tag YWZ-2442.
He may be in the Harnett County area. He also has connections in Rhode Island and Missouri.
If you have any information about Demello's whereabouts, call the Halifax County Sheriff's Office at (252) 583-1991.