Ryan Patrick Hare, 19 is charged with first-degree murder in the death of 18-year-old Matthew Silliman in December, 2008.
Three other teens accused in the murder - Aadil Shaaid Kahn, 18, Allegra Rose Dahlquist, 19, and Drew Logan Shaw, 18, are expected to testify against Hare.
Kahn and Dahlquist have already entered guilty pleas to two counts of conspiracy, attempted murder, and second-degree murder in a plea agreement with prosecutors. They will be sentenced after Hare's trial. Shaw is also said to be cooperating, but has not entered a plea.
Sheriff's investigators found Silliman's body on the bathroom floor of an empty mobile home near New Hill in southwestern Wake County on December 3, 2008.
According to the medical examiner, the Eagle Scout was drugged and suffocated.
Prosecutors allege Hare planned Silliman's death because he was upset after learning of a relationship between Silliman and Dahlquist.
Dahlquist and Khan were classmates at Apex High School with Silliman at the time of his death while Shaw was a sophomore at Panther Creek High School. School officials have said Hare withdrew from Panther Creek earlier in 2008.
All of the defendants, except Hare, were under 18 at the time of the alleged murder.