Fifty-six-year-old Wilma Edwards, also known as "Miss Betty," was last seen on the evening of September 19 by family members along Black and Decker and Legion Roads.
She was on foot carrying a white bucket with a red top and was wearing African attire.
Cumberland County deputies spent most of Monday afternoon canvassing an area near Highway 301 looking for her, but have had no luck.
Edwards' family says she has medical problems that require medications and she has been without them for several weeks.
Detectives say no money is missing from her bank account and they've checked bus and train stations, hospitals and her previous addresses, but to no avail.
Edwards is known to frequent areas along Murchison and Shaw Roads. She is a black female, five feet five inches tall and weighs 165 pounds. She has short cropped gray hair and hazel eyes.
Anyone who has seen Edwards, or knows of her whereabouts, is urged to contact the Cumberland County Sheriff’s Office at (910) 323-1500.