They're double dosing this weekend. Saturday tens of thousands will arrive for homecoming and Sunday will be Halloween and lots of celebrating on Franklin Street.
"We're part of the UNC community so we embrace; we embrace that here at UNC hospitals," UNC Emergency Preparedness Director Dalton Sawyer said.
Sawyer says they are prepared with more nurses and doctors in house and on call.
"Maybe some trips, some falls, maybe people are sick, maybe they had a little bit too much to drink," Sawyer said. "We're looking at ways that we can maximize our efficiency; make sure the hospital continues to run as if it's a Wednesday night."
Sawyer and other hospital leaders have already identified alternate routes for emergency vehicles coming in and key medical staff members for special response.
"We've staged some emergency equipment at strategically locations the hospital so if we need that it'll be readily accessible to us," Sawyer said.
Three hundred officers from Chapel Hill and surrounding agencies will also be on duty.
To keep the party tight, at 9 p.m. officers will shut down portions of Franklin, Columbia, Raleigh and Henderson streets with the hope to end by 11:30 p.m.
For more information about the Halloween rules and detours in Chapel Hillclick here.