It happened at the intersection of Brassfield Road and Hays Road.
Officials said the bus was coming from GC Hawley Middle School with 26 students on board. There were two minor injuries.
Pictures from Chopper 11 HD showed the bus with a damaged car nearby. No one in the car was hurt.
Officials said the injured students were treated by EMTs at the scene and released to their parents.
The cause of the crash is under investigation.