The North Carolina Highway Patrol says it happened at the Aviation Parkway exit.
It all began when a motorist hit a deer after 1 a.m.
Another vehicle hit the first, and then another vehicle coming down I-40 was not able to slow down and hit the guardrail.
The driver of that vehicle was trying to move his car to the side of the road and was hit by a fourth vehicle.
One person had to be cut out of their car by firefighters, but none of the injuries were serious.
Troopers say the accidents are yet another reminder that this is deer mating season and they're very active, so watch out on the roads.