Young's first trial ended last June in a mistrial with the jury deadlocked at eight-to-four to acquit.
The following month, Young, 37, was released from jail after posting a $900,000 bond. He had been behind bars since he was arrested in 2009.
Young claims he was away on a business trip in Virginia on Nov. 3, 2006 when his wife was killed.
Michelle was five months pregnant when she died. Prosecutors said the couple had a long history of marital problems and Jason had affairs with multiple women in the months before the murder. The Youngs' daughter Cassidy - who was 2-years-old at the time - was found unharmed next to her mother's corpse. Investigators said her tiny bloody footprints were tracked throughout the upstairs floor of the home.
In an unusual move for a murder trial, Young took the witness stand in his own defense. He admitted he was a less than perfect husband, but said he was working on his marriage and didn't kill his wife. He said he was asleep in a Hampton Inn in Hillsville, Va. when the murder happened. Prosecutors said he had time to drive back to Raleigh, kill Michelle, and then drive back again.
There's no word if Young will take the stand this time around.
Opening statements are scheduled to begin Monday. Wake County's assistant district attorney has said she expects the new trial to last about six weeks.