Officials said they were called to the Studio Plus Hotel on Wake Town Drive Thursday around 11:40 a.m.
When police arrived, they found 24-year-old Stephen Curtis Hoyle dead inside a guest room.
Friday, police arrested 21-year-old Noureddine Oumous and 25-year-old William Michael Estes. Both are charged with murder.
Police say 25 year-old Charles Dyvonne Estes has been charged with accessory after the fact to murder and with possession of a firearm by a convicted felon in connection with the homicide.
The investigation of the case is continuing. Anyone with information on the case is asked to call Raleigh Crime Stoppers at (919) 834-HELP.