Brenner, who was a sports reporter for WTVD in the 1980s, died Monday night.
WGHP-TV reports Brenner was attending the American Red Cross' "Salute to Heroes" event in Greensboro Monday evening when he had a heart attack and collapsed.
He was then taken to Moses Cone Hospital, where he was later pronounced dead.
Brenner was 65 years old.
The veteran sports anchor also worked in Portsmouth, Va., and Chicago before retiring from WGHP-TV in 2008 after 21 years.