A tractor trailer overturned and caught fire on the median of the highway just after 7 p.m.
The wreck happened near the New Hill Holleman Road exit.
Both directions of U.S. 1 were closed for most of the evening while fire crews put out the blaze.
Troopers told ABC11 that the big rig started to merge when the vehicle hit the jersey barrier on the right and eventually went over a guardrail.
No one was injured.