Dr. Daniel McMahon said the "school community is saddened and hurt by the actions of these few who do not reflect the character of the community."
The Washington Post first reported that the DeMatha Catholic High School team travelled to Durham to play Hillside last Friday night.
McMahon said 18 chaperones travelled with the 65 team members.
"As on all field trips, we conducted room checks and monitored hallways. The last bed checks were at 1:30 a.m. Saturday morning and the hallways were monitored until after 4:30 a.m. The incident referred to in the newspaper occurred after 5 a.m. on Saturday morning," he explained.
The Post reported that some players hired prostitutes from a call service and had sex with them in their hotel rooms - according to a parent with knowledge of the situation.
The Post said five players were removed from the team after an investigation.
"We come from a faith tradition that emphasizes that we tell the truth and support one another. I cannot, either legally or morally, speak to any disciplinary matters," said McMahon.
McMahon said authorities have been informed. ABC11 has learned the team was staying at a Holiday Inn in Morrisville. The general manager of the hotel said the team stayed at the hotel two nights in late August.
The manager said the team was adequately chaperone and drew no complaints during their stay, but management has since been approached by law enforcement.
The Morrisville Police Department is investigating.
The DeMatha Stags won Friday's game 52-14.