The accident happened around 10:30 p.m. at the intersection of Glenwood Avenue and Ebenezer Church Road.
Authorities said 26-year-old Stephanie Anne Smith was traveling east on Glenwood Avenue near Ebenezer Church Road when her 2006 Toyota SUV ran off the road, crossed the median, and drove into the westbound lanes of Glenwood Avenue.
Her vehicle then struck a 2001 Toyota SUV driven by 56-year-old Lidia Del Valle Armeniakos. Armeniakos was taken to Duke University Hospital, where she died a short time later.
Smith was taken to WakeMed with non life-threatening injuries. She was later charged with misdemeanor death by motor vehicle.
The investigation is still ongoing at this time. Further details have not been released.