Officers responded to the intersection of Nebo Street and Burlington Avenue around 11:15 a.m.
When police arrived at the scene they found a male victim in the driver's seat of a vehicle who had been shot.
Police have identified the victim as 17-year-old Kaaylon Pamplin, of Durham. Pamplin was transported to Duke Medical Center with life-threatening injuries. Eyewitnesses told ABC11 Pamplin is a student at Hillside High School.
Police are now searching for a red or burgundy Dodge Magnum with dark tinted windows.
Anyone with information is asked to call Crime Stoppers at (919) 683-1200.