Workers across the country have been on strike since last week against an 8 percent across the board pay cut set for next year.
The Irving, Texas, company said the strike crippled its ability to make and deliver its products at several locations.
Hostess has already closed three bakeries. Friday's decision to close up shop will cost 18,500 workers nationwide -- including bakery employees in Rocky Mount -- their jobs.
The iconic baking company, that also makes Ding Dongs and Wonder Bread has been trying to reorganize after filing for Chapter 11 bankruptcy protection in January. The company just emerged from bankruptcy protection in 2009 after filing in 2004.
The company's plant in Rocky Mount employs 275 people.