It happened at the Sleep Inn on Page Road in Durham on Nov. 9.
Police said a woman told officers that she heard a knock on her room door around 5:30 p.m. and opened it.
When she did, two men entered her room and allegedly pointed a gun at her, then took her laptop, iPad, money and purse.
Police said the suspects returned about seven hours later and stole the woman's 2006 Lexus from the hotel parking lot. The car was found five days later on Rochelle Street.
Anyone with information is asked to call Investigator Smith at (919) 560-4415, ext. 29312 or CrimeStoppers at (919) 683-1200.