It happened around 7:30 p.m. in the westbound lanes of I-440 between Poole Road and New Bern Avenue.
Authorities said 26-year-old April Lichelle Alston of Raleigh was reportedly lying in the roadway when she was hit. It was unclear why she on the interstate.
Further details surrounding the incident have not been released.
All lanes of I-440 were shutdown briefly as authorities investigated the accident. Eastbound lanes were quickly reopened, while westbound traffic was back to normal a few hours later.