It happened just before 7:30 p.m. at the Speed EEZ convenience store.
Sheriff's investigators said two men, one armed with a shotgun and the other with a pistol, entered the store and held the store's clerk at gunpoint while they emptied the cash register.
Investigators said they believed the suspects fled the scene in a vehicle after the robbery. The store's clerk was not hurt.
Surveillance footage of the robbery can been seen online.
The suspect seen carrying the shotgun was described as a slim-build African American man standing between 5 feet 6 inches tall and 5 feet 8 inches tall. He was wearing a black coat with a hood, a scarf over his face and dark-colored pants.
The second suspect armed with the pistol was described as a medium-build African American man standing between 5 feet 9 inches tall and 5 feet 11 inches tall. He is also wearing dark-colored clothing with a hood and a scarf over his face.
Anyone with information about the robbery is asked to call Detective Helsius at (919) 560-0857 or Durham CrimeStoppers at (919) 683-1200.