Police said two adult males were shot and taken to the hospital in private vehicles before officers arrived on scene.
Both males were being treated for serious injuries.
Police also responded to a second shooting just a few hours later.
It happened in the 1000 block of Drew Street where a 24-year-old man was shot in the head during a drive-by shooting.
The scene was just off Alston Avenue, near Juniper Street. The man was listed in critical condition.
The suspect vehicle is described as a silver or gray newer model Nissan Altima with multiple occupants.
Anyone with information is asked to call Investigator Evans at (919) 560-4440, ext. 29336 or CrimeStoppers at (919) 683-1200. CrimeStoppers pays cash rewards for information leading to arrests in felony cases and callers never have to identify themselves.