It happened around 1:30 a.m. near exit 177 at NC-55 and Avondale Drive in Durham.
Authorities said an 18-wheeler carrying produce collided with a car transport truck and overturned, blocking multiple lanes.
The driver of the big rig had minor injuries and was taken to the hospital to be checked out after being pinned in the wreckage. The other driver was treated at the scene by EMS.
Authorities said debris was scattered about one-half mile down the interstate.Crews worked for hours cleaning up the scene.
Further details about the accident, including pending charges, have not been released at this time.