The group was formed after the deadly school shooting in Newtown, Connecticut. Nate and Cleo Pendleton, whose 15-year-old daughter Hadiya was shot and killed at a South Side park, took part in the march.
"Different needs to happen. Unfortunately there have been laws that were very important that made sense that were not passed," Cleopatra Cowley-Pendleton said.
The marchers want a ban on assault weapons and background checks for all gun and ammunition purchases. Organizers said the Chicago march was one of 20 held nationwide over Mother's Day weekend.