It happened on Duke Street in Durham just before 9 p.m. Troopers were conducting a license check on Roxboro Street when the SUV made an abrupt u-turn before reaching the checkpoint, according to officials.
Troopers tried to stop the vehicle, but a short pursuit began. The driver lost control on Duke Street at Leon Street, hitting a tree.
Both the driver and passenger of the vehicle were injured and were transported to Duke Medical Center. Their conditions are unknown.
Officials identified the driver as Jeremy Reshad Spencer and the passenger is Shavonte Cousins, both of Durham.
Troopers said charges are pending.