Officials said a 12-year-old boy and girl were struck them at the intersection of Pine Knoll Drive and Manhasset Lane around 6:15 p.m.
The victims have been identified as Ariana Mack and Cameron Clarkson-Blake.
Both were taken to WakeMed. Clarkson-Blake is listed in critical condition, while Mack was treated and released.
Police said the crash is still under investigation.