Investigators said 44-year-old Carol Jean De Olloqui, of Sandy Bluff Road, is charged with three counts of animal cruelty.
De Olloqui was the most recent president of Calvin's Paws, a nonprofit animal rescue program.
Officials with the Wake County Animal Shelter said conditions at the home were unfit for the cats and dogs, with animal waste scattered about the home. An arrest warrant accuses her of depriving the animals of food, water and medical care.
Wake shelter director Jennifer Federico said they were able to save about 30 cats, but 60 of them had to be euthanized. Federico said most of the cats had conditions including respiratory infections, ulcers, emaciation or dehydration. A few of the cats appeared to be healthy.
Safehavenforcats.org has 8 of the cats. They hope to have them ready for adoption soon.
The Wake County chapter of the Society for the Prevention of Cruelty to Animals has 14 of the cats and three dogs. The rest of the cats are at the Wake County shelter and two other rescue groups.
Calvin's Paws current president, Dan Wagner, issued a statement saying the rescue organization does not support the practice of foster owners' taking on a large number of animals.