A full jury of seven men and five women has been seated, but attorneys still need to choose two alternates.
If they are picked in the morning, the trial could start immediately after that.
Mangum is charged with stabbing her boyfriend, Reginald Daye, with a kitchen knife during an argument in April 2011. Daye died 10 days later.
Mangum claims it was all in self defense and that a medical error was to blame for Daye's death.
Mangum made national headlines in 2006 when she accused a group of Duke University lacrosse players of sexually assaulting her while she worked as a stripper at a party. The accusations were later found to be false, and Attorney General Roy Cooper dismissed all charges filed against the students.
Mangum has gone through several attorneys - who asked to be removed from the case - and even represented herself for a time.
The revolving door of defenders pushed back her trial date for years. She is charged with first-degree murder, assault with a deadly weapon, and larceny.