Police followed the 1993 white Cadillac to National Drive off Snow Hill Road, which is where the chase ended around 12:40 a.m.
Officials say the suspect struck the detective's vehicle, and then rammed an additional police car.
After the crash, shots were fired, and the driver of the car was hurt and taken to the Cape Fear Valley Medical Center.
Authorities say a passenger managed to escape on foot, and is still at large.
Police say an officer was also injured in the incident, but has since been treated and released from the hospital.
The driver, 25-year-old Kevin Dejon Grissett, passed away as a result of his injuries.
The SBI is investigating.