It happened at a home in the 100 block of Javelin Court, near Clayton, on Friday afternoon.
The Johnston County Sheriff's Office said Andrew and Ryanne Gardner lived in the home. The sheriff's office also called it a meth lab of exceptional size.
The sheriff's office told ABC11 that a domestic abuse call from the couple turned into a bust when deputies found components of a meth lab.
The environment was so toxic that emergency officials said three people needed medical treatment when they arrived.
The Gardners are in the Johnston County Jail charged with maintaining a dwelling to manufacture meth.
Neighbors in the tightly knit Summerset subdivision told ABC11 that the couple had lived in the home for a while, and were involved in the community, attending cookouts, and sporting events with their children.
However, they said things turned sour about a year ago between 32-year-old Ryanne and her husband. In February, she was arrested for possessing drug paraphernalia.
Neighbors described the downward spiral, and turn of events as shocking, disappointing, and disturbing.
It's not officially known what will come of the house, but a neighbor told ABC11 that the home is so contaminated that it will have to be torn down to the foundation.
That same neighbor said the couple's children were not home when the bust happened.