According to ABC11 crews on the scene, just before 7:30 a.m., the woman was driving a Toyota south I-95 when he or she crossed the median and crashed into a Pepsi truck.
Authorities have yet to release the person's identity; however, they said she is from Alabama.
ABC11 is working to learn the status of the other driver.
The roadway was closed just before 9 a.m.
Drivers should find alternate routes.