All four are charged with first-degree murder in the death of Hong Zheng, the owner of China Wok, who was attacked and shot to death in his driveway in the 4600 block of Carlton Crossing Drive on April 15.
Maurice Owen Wiley, Jr., 28, was arrested and charged last month.
Now, 21-year-old Hykeem Deshun Cox, 18-year-old Darryl Bradford, 18-year-old Semaj Maleek Bradley, and 18-year-old Charles Winfor Daniels are also facing charges.
All five men are being held in the Durham County Jail without bond.
Zheng's family said they believe he was targeted, following a string of robberies during the past few years.
Cyndy Yu-Robinson, a board member for North Carolina Asian Americans Together, said targeted attacks on Asian American businesses have spiked during the past four years.
"It's perceived that Asians have a cash-based business, they're unarmed, they're defenseless and they may have language barriers where they can get help," said Yu-Robinson.