The National Weather Service urged drivers in 28 central counties to watch for slick roads during the morning commute.
Slick roads will be a problem on bridges and on some less-traveled roads.
Two motorists have died in crashes due to weather conditions.
Lonnie Nobles Madry, 45, of Tarboro was killed Wednesday morning. The wreck happened when Madry's car hit an icy patch and skidded into a tractor-trailer on North Carolina Route 97 in Edgecombe County.
Authorities say Madry was driving too fast for conditions on the icy rural road when his car slipped on ice on a shady curve and crossed the center line. The car collided with a truck driven by William DeJesus, 30, of Castalia, Young said. DeJesus wasn't injured and will not be charged.
Another driver died Tuesday in Granville County when his vehicle skidded off a road and hit a tree.
Temperatures were below 30 degrees across much of the state before dawn Thursday. Forecasters said readings will rise into the 40s in the afternoon.
The advisory covers counties from the Virginia to South Carolina borders and includes Durham, Rocky Mount, Albemarle and Clinton.