It happened around 10 p.m. in the 4200 block of Delbert Avenue, which is off of Horton Road.
Police said one person was found inside an apartment and the other person was found outside. Both were rushed to Duke University Medical Center.
Authorities said one victim was 17-years-old and the other appeared to be in his early 20s. The extent of their injuries are unknown at this time.
Further details about the incident have not been released.