The accident happened around 7 a.m. when a truck carrying ammonium nitrate slurry and blasting caps overturned. No other vehicles were involved.
Randolph County Emergency Services Director Donovan Davis told WGHP in High Point that everyone within a half mile radius of the accident was advised to evacuate the area, including a nearby elementary school.
According to WGHP, the driver of the truck was transported to High Point Regional, then flown to Wake Forest Baptist Medical Center with unknown injuries.
The company that owns the truck, Orica, said it was carrying blasting materials for use at a local mining quarry site. A spokesperson said there was less than 100 pounds of material on board when the accident happened.
Officials said the explosives inside the truck appeared to have stayed inside packaging despite the crash. As a precaution, emergency personnel eliminated all ignition sources.
The southbound lanes were reopened just after 3 p.m. and the northbound lanes were reopened about four hours later.