It happened around 9:45 p.m. on Vandora Springs Road near West Garner Road, and involved an Amtrak train.
Right now, it is unclear what caused the crash at the guarded crossing. Signals appeared to be working at the time of the crash.
Amtrak officials told ABC11 the Silver Star, which was bound for Miami, struck a vehicle that was obstructing the tracks.
There's no word yet on the victim's identity.
There are no reports of any injuries to the train's passengers.
The train is expected to continue its trip after the investigation is complete.