It happened around 10:40 p.m. on U.S. Highway 1 about two miles north of Midland Road.
Authorities tell ABC11 that 36-year-old Tyrell Abbott of Alston, Texas was driving his Toyota 4Runner in the wrong direction when he crashed head-on with a Toyota sedan that was driving in the northbound lane.
The force of the impact caused Abbott's SUV to catch on fire.
Abbott and the driver of the sedan, 20-year-old Jasmine Wicker of Sanford, were killed. No one else was inside the cars.
Wicker's family members are clinging to their faith and each other for support. They say she had so much to live for.
"It hurts, and I have my moments. She is my baby. I am okay," said Wicker's aunt, Scherica Johnson. "God has brought a peace over me that surpasses all understanding."
"She never made enemies," said Wicker's uncle, Travis Watson. "Every time we saw her she would always smile. She had just a tiny voice like a little angel. She will be missed."
The family says they want everybody to pray for them to give them that kind of strength and peace in the coming days and weeks.
State troopers are still investigating the accident, and they haven't said how or why Abbott drove in the wrong lane, or if speed, or alcohol were involved.