It happened around 1 a.m. along westbound I-40 at exit 282, near Page Road.
Authorities tell ABC11 that the driver, 25-year-old Qianyu Hang, was going the wrong way down the interstate when they collided with a FedEx semi-truck.
Wrong way driver shuts down part of WB 40 at exit 282... driver of this car is in critical but stable condition at Duke.— Julie Wilson (@JulieABC11) December 13, 2017
Driver of other Vehicle appears to be okay. The latest on @ABC11_WTVD #abc11 pic.twitter.com/yuOTTETj2Z
Authorities said there had been 911 calls about Hang driving the wrong way before the crash.
Officials said he was taken to the hospital in critical condition and had just got a North Carolina driver's license a few weeks ago.
The driver of the truck, 68-year-old Tyrone Hines, was not hurt.
Several lanes of I-40 were blocked for several hours as authorities cleared the scene.
FedEx has issued this statement:
"Our thoughts and prayers are with the families of those involved in this accident, and we are cooperating with local officials as they investigate. In cases of damaged freight, we have measures in place to immediately recover as much as possible and communicate with our customers."