In an interview with the Sunday Times of London, Goodman said he wasn't sure how the new series, titled "The Conners," will be structured.
But he guessed that his character will be "mopey and sad" because his wife has died.
Goodman played husband Dan Conner to Barr's character on ABC's original "Roseanne" and last season's revival.
The network fired Barr after she posted a racist tweet, which she apologized for but has said was misinterpreted.
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Goodman said he's certain Barr isn't a racist.
"The Conners" spinoff was announced by ABC after Barr agreed to relinquish any participation in it.
"There is going to have to be a dramatic way to address why she wasn't on the show," said Michael O'Connell, senior writer for "The Hollywood Reporter. "Killing off the character of Roseanne Conner seems like the most natural way of getting rid of Roseanne Barr."
O'Connell added, "The revived season that aired in the spring, ended with her going in for knee surgery. It seems like a natural way to cue up that character dying."
Goodman also shared his feelings about the ordeal, saying that he went through a period where he was "depressed" after the show was canceled.
"I was brokenhearted, but I thought, 'OK, it's just show business, I'm going to let it go,'" Goodman said. "But I went through a period, about a month, where I was very depressed."
A representative for Goodman didn't immediately respond to a request for comment.
"The Conners" premieres October 16 at 8 p.m. on ABC.
Disney is the parent company of ABC and ABC11.
The Associated Press contributed to this report.