It happened about 9:10 p.m. at N. Hyde Avenue and Lowry Avenue, in east Durham.
A 59-year-old woman was hit by a vehicle that did not stop. Police found her lying in the street.
Police said the victim was taken to the hospital for treatment of serious, possibly life-threatening injuries.
Police did not have immediate information on the suspect vehicle.
Anyone with information is asked to call CrimeStoppers at (919) 683-1200. CrimeStoppers pays cash rewards for information leading to arrests in felony cases and callers never have to identify themselves.