Biden will be a guest Wednesday night on ABC's "Jimmy Kimmel Live!" the White House said.
Kimmel tweeted Sunday: "Our very elected President @JoeBiden visits @JimmyKimmelLive Wednesday night. No malarkey."
Biden travels Wednesday to Los Angeles to host the Ninth Summit of the Americas, and Kimmel's show tapes in Hollywood.
In December 2021 Biden appeared virtually on NBC's "The Tonight Show" with Jimmy Fallon, his first late-night appearance while in office.
Government leaders from across the hemisphere will gather to discuss economic prosperity, climate change, the migration crisis and the COVID-19 pandemic, the White House said. Biden will give the summit's opening address on Thursday.
"Jimmy Kimmel Live!" airs weeknights at 11:35|10:35c on ABC.