Officials say George Knisley IV, of Maryland, was apprehended following a pursuit Friday night with the Raleigh Police Department.
Knisley is suspected of having stolen a third car in North Carolina before he was caught.
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The Cumberland County Sheriff's Office of Virginia said Knisley was also wanted for questioning in the disappearance of 43-year-old Renee Fabian of Cumberland, Virginia.
Authorities are actively following up on leads related to the disappearance of Fabian.
Knisley is being held on a first degree murder charge. Additional charges are pending.