"I've said I would continue on as long as there was a viable path to victory; tonight I'm sorry to say it appears that path has been foreclosed," Cruz told a somber crowd in Indianapolis.
Cruz campaigned aggressively in Indiana, but could not overcome Trump.
The billionaire businessman has stunned the Republican Party with his appeal to voters deeply frustrated with Washington and their own party's leaders.
Trump called Cruz a very tough competitor with an amazing future. (See video below)
Trump still must win about 200 more delegates to clinch the nomination. But his victory in Indiana - where he picked up at least 45 of the state's 57 delegates - made it all but impossible for Cruz to block him from doing so.
Before Tuesday's results, Cruz had vowed to stay in the race through the final primaries in June, clinging to the possibility that Trump would fall short of the 1,237 delegates he needs and the race would go to a contested convention.
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