Pictures from the scene showed the Dodge Durango ran off the highway and into a wooded area full of trees around 2:30 p.m.
Troopers said there were seven people in the SUV from South Carolina who were headed to a family reunion in a convoy of vehicles.
The driver, 33-year-old Reginal Reddish, and three of his passengers, 31-year-old Jennifer Reddish, 13-year-old Kordale Sapp, and 2-year-old Reginal Reddish Jr., all died at the scene.
Deangelo Washington, 15, Rejerra Reddish, 4, and Faye Cushman, 7, were all seriously injured. They were taken to Cape Fear Valley Medical Center.
Washington was listed in serious condition as of Saturday morning. Rejerra Reddish and Cushman were both said to have non-life threatening injuries.
Authorities said Reginal and Jennifer Reddish were husband and wife. Reginal Jr. is their son. Kordale Sapp is Jennifer Reddish's son and Reginal Reddish's stepson.
According to troopers, Deangelo Washington is Reginal Reddish's stepson and Jennifer Reddish's son. Rejerra Reddish is their daughter. Faye Cushman is Jennifer Reddish's niece.
The cause of the crash was under investigation. It happened right where the on-ramp from Highway 87 merges with the interstate.
Veteran troopers called the accident scene disturbing.
"You've got four confirmed fatalities involved and all of them are part of a family. It's very difficult especially when you have new troopers who have never experienced anything like this before," explained Sgt. Charlene Cotton with the North Carolina Highway Patrol.
Interstate 95 northbound was shut down while troopers investigated. Traffic was backed up for miles.
Investigators are requesting any witnesses to the collision please contact the Highway Patrol at 1-800-334-7411 as the collision is still under investigation.
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