"Now, it's been a little challenging week for me," Burr said to laughs from the audience at a lecture forum for The Jesse Helms Center.
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Outside the Raleigh hotel, there were loud reminders of the controversies Burr finds himself in the middle of. Protesters demanded Burr take a tougher stance against President Donald Trump's abrupt firing of FBI director James Comey.
"Clearly, the president lost trust in James Comey," Burr told Triad TV station WGHP earlier Friday. He was also asked about the president's eyebrow-raising Twitter storm on Friday morning.
President Trump tweeted, "Comey better hope that there are no 'tapes' of our conversations before he starts leaking to the press!"
Burr called the comments, "inappropriate."
"It's important that the president realize that the world demands American leadership. American leadership starts with the president of the United States," Burr told WGHP.
Back at the Sheraton, the senator only alluded to his new stresses on Capitol Hill.
"This year, as I like to say, every day is a Monday," Burr quipped.
Burr declined reporter's attempts for interviews after his remarks. Staffers quickly hurried him out of the hotel through a fire-exit door.
The state's junior senator, Thom Tillis, who spoke at the hotel earlier Friday also seemed unenthused about taking more questions regarding Trump's actions.
ABC11 reporter Jonah Kaplan tracked down Tillis in the hotel hallway to ask for Tillis' thoughts on the president's firing of Comey.
"It's not the way I would've done it," Tillis said before being whisked away by staff.
READ MORE ABOUT TILLIS' VISIT TO RALEIGH HERE
Tillis' and Burr's appearances in North Carolina come as the news hit that Comey has declined Burr's invitation to appear before the Senate Intelligence Committee next Tuesday.
Burr said his staff would likely work something out in the near future for a private meeting with Comey instead.
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