Pujols left in the third inning Monday night after his three-run drive down the left-field line.
The three-time NL MVP held the back of his left leg as he slowly jogged to second base while Mike Trout slid under the cutoff man's throw at home.
After manager Mike Scioscia and the Angels' training staff checked on him, Pujols left the field walking smoothly.
Pujols has 97 RBIs this season. His three-run double tied him with Mike Schmidt for 35th place in baseball history with 1,595 RBIs.