Cory Gensler made 5 of 8 from the field, including two 3-pointers, and scored 12 for Campbell (2-2).
It was the second straight 30-plus point performance by Burk, a 6-foot-3 sophomore who had 33 points and hit eight 3s - both career highs - in an 88-84 loss to UNC-Wilmington on Saturday.
Burk scored 14 points, including four 3-pointers, during a 19-9 run to open the game and the Camels led the rest of the way.
Gensler had a layup and hit a 3 as Campbell scored 14 straight points to make it 49-22 late in the first half. Jon Ander Cuadra, who had all of his 12 points in the second half, scored six in a row to give Campbell its biggest lead, 98-51, in closing seconds.
With the nation's sixth-leading scorer, Chris Clemons, sidelined by injury, Campbell had 25 assists on 35 made baskets. Campbell converted 16 Johnson & Wales miscues into a 20-9 edge in points off turnovers and finished with a 44-27 edge on the glass.
Robert Hobson led Johnson & Wales, a member of the United States Collegiate Athletic Association, with 12 points.
The Camels host the Creek Classic during Thanksgiving Weekend. Campbell opens the event on Friday in a 2 p.m. tip-off against Abilene Christian, followed by Bowling Green vs. USC Upstate at 5 p.m.
The Creek Classic continues Saturday and Sunday at Gore Arena. Tournament passes for all six games are just $20.
The Associated Press contributed to this report.