In the deal, which includes the Washington Nationals, San Diego also receives catcher Ryan Hanigan, left-hander Jose Castillo, and right-hander Gerardo Reyes from the Rays.
Heading to Tampa Bay is right-hander Burch Smith, first baseman Jake Bauers and catcherRene Riverafrom the Padres, and outfielder Steven Souza and left-hander Travis Ott from the Nationals.
Washington will receive right-hander Joe Ross and shortstop Trea Turner as a player to be named later on June 14.
The Padres agreed to a deal for Matt Kemp of the Los Angeles Dodgers last week, and Myers would give an additional boost to a San Diego offense that ranked last in the majors with 535 runs scored and a .634 OPS in 2014.
Myers, 24, was a third-round pick by Kansas City in the 2009 first-year player draft. After he finished second in the minor leagues to Philadelphia's Darin Ruf with 37 home runs in 2012, the Royals sent him to Tampa Bay as part of a seven-player trade that brought pitchers James Shields and Wade Davis to Kansas City.
Myers hit .293 with 13 homers in 88 games in winning the American League Rookie of the Year Award in 2013. He was limited to 87 games because of a fractured right wrist in 2014 and hit only .222 with six homers and a .614 OPS in 325 at-bats.
A.J. Preller, San Diego's new general manager, has been aggressive this offseason. The Padres fell short in free-agent pursuits of Pablo Sandoval and Cuban outfielder Yasmany Tomas before focusing their attention on trades.
Padres Nearing Deal For Rays' Myers
Jerry Crasnick discusses what the addition of outfielder Wil Myers would mean to the Padres' lineup.