The No. 22 Tar Heels will face the Wildcats at 2 p.m. ET, and the No. 20 Buckeyes and Bruins will tip off at 4:15 p.m. in Rocket Mortgage FieldHouse.
Organizers said the change was to "more closely align COVID-19 testing protocols between the competing programs and their respective conferences." The schools come from the ACC, SEC, Big Ten and Pac-12.
Originally, Kentucky was playing UCLA and North Carolina against Ohio State.
The four schools have combined for 26 national championships and 65 Final Four appearances.
Duane Washington weaves through defense for easy bucket
Ohio State's Duane Washington Jr. uses his handles to weave through the Cleveland State defense and finish at the cup for an easy lay-in.