Clemson moved up two spots to No. 3 in The Associated Press college football poll after a dramatic victory against Louisville and is one of six Atlantic Coast Conference teams ranked, matching the Southeastern Conference for the most teams ranked.
Alabama remained No. 1 and had 53 first-place votes and Ohio State held on to No. 2 after a weekend where 10 Top 25 teams lost.
Louisville, also from the ACC, slipped four spots to No. 7. It's the first time since 2006 that the ACC has six ranked teams.
Michigan remained No. 4, and No. 5 Washington moved up five spots after a dominant victory against Stanford. The last time the Huskies were ranked this high was 2000, when they won the Rose Bowl and finished No. 3 in the nation.
No. 10 Miami, which moved up four spots, gives the ACC three in the top 10 to also match the SEC in that category.
Ten ranked teams losing was the most in a regular-season week since Oct. 4, 2014, when 11 ranked teams went down, five to unranked teams. All the upheaval resulted in only four teams holding the same rankings they had last week: Baylor at No. 13 was the fourth, along with Alabama, Ohio State and Michigan.
Joining the rankings were:
No. 21 Colorado (4-1), which is ranked for the first time since Nov. 6, 2005. Fourth-year coach Mike MacIntyre, who came into the season with 10 victories at CU, has the Buffaloes off to their best start since that 2005 season when they also went 4-1 before finishing 7-6.
No. 23 West Virginia, ranked for the first time this season and one of only two remaining unbeaten teams in the Big 12 with Baylor.
No. 25 Virginia Tech, which slipped into the rankings for the first time since Sept. 7, 2014, during an off week.
No. 17 North Carolina, which jumped back into the rankings after beating Florida State with a last-play field goal. The Tar Heels have won four straight since an opening loss to Georgia.
No. 20 Oklahoma, back in the rankings after one week out.
Falling out of the rankings were:
Michigan State, which has lost consecutive games for the first time since 2012 and is unranked for the first time since October 2013.
San Diego State, out after having its 13-game winning streak broken 42-14 at South Alabama.
TCU, dropped out after losing at home to Oklahoma.
Texas, gone after its second consecutive loss. The Longhorns made a huge jump into the rankings after week one, but head into the Red River Rivalry against the Sooners unranked for the fourth straight season.
Georgia, after a crushing loss to Tennessee, which was its second straight and left the Bulldogs unranked.
No. 18 Florida and No. 19 Boise State each moved up five places.
No. 23 Florida State fell 11 spots after losing the North Carolina, while No. 15 Stanford dropped eight spots after its first loss. No. 11 Wisconsin slipped three after losing at Michigan.
The Associated Press contributed to this report.