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The wreck happened at Fayetteville Road near Old Stage Road. US 401 is closed in both directions while emergency crews work the scene.
UPDATE: Sheriff’s deputy SUV and silver BMW it collided with now both being towed away. @NCSHP wrapping up crash investigation. U.S. 401 NB and SB could reopen very soon. #abc11 pic.twitter.com/gpTXsEH52t— Joel Brown (@JoelBrownABC11) October 10, 2018
The deputy and the other driver were taken to WakeMed with serious injuries.
On Wednesday, ABC11 learned the deputy involved is John Patrick Carlisle, a seven-year veteran of the Wake County Sheriff's Office.
Carlisle suffered a broken femur and was undergoing surgery Wednesday.
The deputy's SUV was a K-9 unit. His canine partner was not injured in the crash, the sheriff's office told ABC11.
The other vehicle involved was a BMW sedan.
The State Highway Patrol is assisting with the investigation.
#BREAKING: Wake Sheriff’s deputy injured along with other driver in collision that has closed U.S. 401 in both directions in southern Wake County. Both rushed to WakeMed. #abc11 pic.twitter.com/PX430Dbtnz— Joel Brown (@JoelBrownABC11) October 10, 2018
The roadway reopened after several hours.
ABC11's Josh Chapin contributed to this report.